Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :FMK821794-92-7HY-52101A342.37C18H19FN4O2>98%Solubility:DMSOMechanisms: Pathways:MAPK; Target:RSK gyBiological Activity:FMK is a RSK2 kinase inhibitor.References:[1]. FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosinephosphorylation of RSK2 and activation of the MEK/ERK pathway By Kang, Sumin; Dong,Shaozhong; Gu, Ting-Lei; Guo, Ailan; Cohen, Michael S.; Lonial, Sagar; Khoury, Hanna Jean; FCancer Cell. 2007 Sep;12(3):187-9.p() [2]. Cuello F, Snabaitis AK, Cohen MS, Taunton J, Avkiran M. Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation andactivity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and specific RSK inhibitor fmk onresponses to alpha1-adrenergic stimulation. Mol Pharmacol. 2007 Mar;71(3):799-806. [3]. Cohen JD, Babiarz JE, Abrams RM, Guo L, Kameoka S, Chiao E, Taunton J, Kolaja KL. Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity andelectrophysiological alterations. TilAlPhToxicol Appl Pha...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 080,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
