Insulin derivatives, their use and a pharmaceutica

专利名称：Insulin derivatives, their use and a

pharmaceutical composition containing same

发明人：DORSCHUG, MICHAEL, DR.申请号：EP120462.0申请日：191106公开号：EP0368187A3公开日：19910703

摘要： New insulin derivatives of the formula II with an isoelectric point of from 5 to8.5, with improved stability in weakly acidic aqueous medium as well as with special-effectprofile and the physiologically tolerated salts of these insulin derivatives for thetreatment of diabetes mellitus; Formula II is: in which R¹ is H or H-Phe, R² represents agenetically encodable, containing no amide group L-amino acid, R³⁰ represents the radicalof a neutral, genetically encodable L-amino acid, R³¹ represents a physiologically

acceptable organic group of basic character having up to 50 carbon atoms, are involved inthe structure of which 0 to 3 α-amino acids and their optionally present terminal carboxylfree to be reduced as Esterfunktion, as amide functionality, a lactone or CH₂OH can, andX represents a genetically encodable L-amino acid.

申请人：HOECHST AKTIENGESELLSCHAFT

地址：D-65926 Frankfurt am Main DE

国籍：DE

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